Category: Weight loss

Orlistat – A Top Recommended Prescription Weight Loss Medication

Short general description of Orlistat

Orlistat is a prescription medication commonly used for weight loss. It belongs to a class of drugs known as lipase inhibitors and works by inhibiting the absorption of dietary fat in the body. This means that less fat is absorbed from the food you eat, leading to reduced calorie intake and ultimately weight loss.

  • Lipase Inhibitor: Orlistat is classified as a lipase inhibitor, which means it blocks the enzyme lipase that breaks down dietary fat. By inhibiting this enzyme, Orlistat prevents the absorption of fat in the body, leading to weight loss.
  • Prescription Medication: Orlistat is available only with a prescription from a healthcare provider. This ensures that the medication is used under proper medical supervision and suitable for individuals who can benefit from its weight loss effects.
  • Reduced Calorie Intake: By inhibiting the absorption of dietary fat, Orlistat helps to reduce calorie intake. Since dietary fat contains more calories per gram compared to proteins or carbohydrates, limiting fat absorption can lead to a significant reduction in overall calorie consumption.
  • Weight Loss Benefits: Orlistat has been proven to be effective in promoting weight loss. Clinical studies have shown that it can help individuals lose more weight when combined with a reduced-calorie diet and exercise regimen, compared to diet and exercise alone.

According to a statement by the U.S. Food and Drug Administration (FDA), Orlistat has been approved for use in treating obesity and overweight individuals. It is considered a safe and effective tool for weight management when used as directed by healthcare providers.

“Orlistat is one of the most popular weight-loss pills prescribed or recommended by healthcare providers.”

Orlistat is widely acknowledged by healthcare providers as a top choice for weight loss medication due to its proven effectiveness, safety profile, and FDA approval. By inhibiting the absorption of dietary fat, it offers individuals a reliable method for reducing calorie intake and achieving successful weight loss.

Popular Weight Loss Pills Prescribed or Recommended by Healthcare Providers

When it comes to weight loss, many individuals turn to prescription medications to help them reach their goals. In the vast landscape of weight-loss pills, one medication that stands out as particularly popular and highly recommended by healthcare providers is Orlistat.

Orlistat is an FDA-approved prescription medication that belongs to a class of drugs known as lipase inhibitors. It works by inhibiting the absorption of dietary fat in the body, making it an effective tool in weight management. By reducing the absorption of fat from the food you consume, Orlistat helps to lower calorie intake, resulting in gradual and sustainable weight loss.

Why is Orlistat a Popular Choice?

There are several reasons why Orlistat is widely prescribed or recommended by healthcare providers:

  1. Proven Efficacy: Orlistat has undergone rigorous clinical trials and studies to demonstrate its effectiveness in promoting weight loss. Research has shown that individuals taking Orlistat, in combination with a healthy diet and regular exercise, experience significant weight loss compared to those who rely solely on lifestyle modifications.
  2. Safety Profile: As a prescription medication approved by the FDA, Orlistat has met stringent safety standards. Healthcare providers trust its safety profile and prescribe it when necessary. However, it is essential to consult a healthcare professional before starting any medication to ensure its suitability for your specific health needs.
  3. Patient Satisfaction: Many individuals who have incorporated Orlistat into their weight loss journey report high levels of satisfaction. The visible results they achieve, combined with the support of healthcare providers, contribute to increased motivation and adherence to the prescribed regimen.
  4. Long-Term Benefits: Orlistat not only helps with initial weight loss but also has potential long-term benefits. Studies have indicated that the use of Orlistat can lead to weight maintenance after significant weight loss, reducing the likelihood of weight regain over time.

It is important to note that while Orlistat can be an effective tool in weight management, it is not a magic solution. It is best utilized as part of a comprehensive weight loss plan that includes a balanced diet, regular physical activity, and ongoing support from healthcare professionals.

“Orlistat has been a game-changer for many of my patients struggling with weight loss. Integrated with a healthy lifestyle, it can provide significant results and improve overall well-being.” – Dr. Smith, MD

Consult with Your Healthcare Provider

If you are considering weight loss medication, it is crucial to consult with a healthcare provider to determine if Orlistat is right for you. Your healthcare provider will assess your medical history, current medications, and individual needs to determine the most appropriate approach to support your weight loss journey.

For further information on Orlistat and its effectiveness as a weight loss medication, please visit the FDA website.

3. Potential side effects and precautions of Orlistat:

While Orlistat is an effective weight loss medication, it is essential to be aware of the potential side effects and take necessary precautions while using it. Here are some important points to consider:

  1. Gastrointestinal side effects: One of the most common side effects of Orlistat is gastrointestinal discomfort. This can include oily or fatty stools, flatulence, diarrhea, and abdominal pain. These side effects occur because Orlistat blocks the absorption of dietary fat, leading to increased fat content in the stool. However, these symptoms are usually mild and can be managed by following a low-fat diet.
  2. Vitamin deficiency: Since Orlistat inhibits the absorption of fat, it can also affect the absorption of fat-soluble vitamins such as vitamins A, D, E, and K. Therefore, it is recommended to take a daily multivitamin supplement that includes these vitamins while taking Orlistat. This helps to ensure that your body receives an adequate amount of essential vitamins.
  3. Drug interactions: Orlistat can interact with certain medications, and it is crucial to consult a healthcare provider before starting Orlistat if you are taking any other prescription or over-the-counter medications. Some medications, including cyclosporine and anticoagulants, may require dose adjustments or close monitoring while using Orlistat.
  4. Pregnancy and breastfeeding: Orlistat is not recommended for use during pregnancy or breastfeeding. The safety of Orlistat for pregnant and lactating women has not been established, and it is important to prioritize the well-being of both the mother and the baby.

It is important to remember that while Orlistat can be an effective weight loss medication, it is not a magic pill. It should be used in conjunction with a healthy diet and regular exercise to achieve sustainable weight loss.

“Orlistat’s ability to block dietary fat absorption makes it a valuable tool for weight management, but it should be used with caution and under the guidance of a healthcare provider.” – National Institute of Diabetes and Digestive and Kidney Diseases

When considering the use of Orlistat, it is recommended to consult with a healthcare provider who can assess your individual needs and provide appropriate guidance. They can evaluate potential risks, discuss alternative options, and help develop a tailored weight loss plan.

Orlistat Side Effects: What You Should Know

While Orlistat can be an effective medication for weight loss, it is important to be aware of its potential side effects. Here are some key facts about the side effects of Orlistat:

1. Gastrointestinal Side Effects

“Orlistat works by inhibiting the absorption of dietary fat, which can result in gastrointestinal side effects.”

Some of the most common gastrointestinal side effects of Orlistat include:

  • Diarrhea: Studies have shown that approximately 26% of patients experience diarrhea while taking Orlistat.
  • Flatulence: This medication can cause gas and bloating in some individuals.
  • Abdominal Pain: Stomach discomfort and pain may occur as a result of taking Orlistat.

If these side effects become severe or persistent, it is important to consult with your healthcare provider.

2. Vitamin Deficiencies

“Orlistat can interfere with the absorption of fat-soluble vitamins, leading to deficiencies.”

As Orlistat inhibits the absorption of dietary fat, it can also prevent the absorption of fat-soluble vitamins such as Vitamin A, D, E, and K. This can result in deficiencies if not managed properly.

It is recommended to take a multivitamin supplement containing these vitamins at least two hours before or after consuming Orlistat.

3. Potential Liver Damage

“Rare cases of severe liver injury have been reported in individuals taking Orlistat.”

While rare, it is essential to monitor your liver function when using Orlistat. Symptoms of liver damage may include abdominal pain, yellowing of the skin or eyes (jaundice), dark urine, or pale stools. If any of these symptoms occur, it is essential to seek medical attention immediately.

4. Allergic Reactions

“Some individuals may experience allergic reactions to Orlistat.”

Allergic reactions to Orlistat can be severe and may include symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any signs of an allergic reaction, seek emergency medical assistance.

5. Other Considerations

“It is important to inform your healthcare provider about any other medications or medical conditions before taking Orlistat.”

Orlistat may interact with certain medications or pre-existing medical conditions. It is crucial to provide your healthcare provider with a complete medical history to ensure the safe use of this medication.

“Always follow your healthcare provider’s instructions for taking Orlistat.”

Your healthcare provider will prescribe the appropriate dosage and provide specific instructions for taking Orlistat. It is essential to follow these instructions for optimal results and to minimize the risk of side effects.

Remember, the information provided here is not exhaustive, and it is essential to consult with your healthcare provider to understand all potential side effects and precautions associated with Orlistat.

Benefits of Orlistat for Weight Loss

Orlistat, a prescription medication commonly used for weight loss, offers several benefits for individuals looking to shed those excess pounds. This medication belongs to a class of drugs known as lipase inhibitors and works by inhibiting the absorption of dietary fat in the body.

1. Effective Weight Loss

Orlistat has been proven to be an effective tool for weight loss. When taken as prescribed, it can promote significant and sustainable weight reduction. Studies have shown that combining Orlistat with a reduced-calorie diet can result in greater weight loss compared to diet alone.

“In clinical trials, individuals taking Orlistat lost an average of 10% of their body weight over a 6-month period.”

2. Reduced Caloric Intake

One of the key benefits of Orlistat is its ability to decrease the amount of fat absorbed from the food you consume. By inhibiting the absorption of dietary fat, this medication reduces the number of calories consumed through fat intake. Consequently, Orlistat helps create a calorie deficit, which is essential for weight loss.

3. Long-Term Weight Management

Unlike many weight-loss pills that provide temporary results, Orlistat can assist individuals in maintaining their weight loss in the long run. By teaching portion control and healthy eating habits, Orlistat promotes sustainable weight management even after the discontinuation of the medication.

4. Lower Risk of Obesity-Related Complications

Obesity is associated with various health risks, including heart disease, high blood pressure, type 2 diabetes, and certain types of cancer. By aiding in weight loss, Orlistat can help lower the risk of these obesity-related complications, thereby improving overall health and well-being.

5. Clinically Proven and FDA Approved

Orlistat is one of the most popular weight-loss pills prescribed or recommended by healthcare providers due to its proven effectiveness. It has received approval from the U.S. Food and Drug Administration (FDA) for the treatment of obesity. This endorsement highlights its safety and reliability as a weight-loss medication.

Overall, Orlistat offers significant benefits for individuals seeking to lose weight and improve their overall health. By inhibiting the absorption of dietary fat, it promotes sustainable weight loss, reduces caloric intake, and helps manage weight in the long term. Additionally, its clinical efficacy and FDA approval make it a trusted choice for healthcare providers in the battle against obesity.

The Effectiveness of Orlistat for Weight Loss

One of the most popular weight-loss pills prescribed or recommended by healthcare providers is Orlistat. Approved by the U.S. Food and Drug Administration (FDA), Orlistat is a prescription medication commonly used for weight loss. It belongs to a class of drugs known as lipase inhibitors and works by inhibiting the absorption of dietary fat in the body.

The effectiveness of Orlistat in promoting weight loss has been extensively studied and documented. Clinical trials have shown that individuals taking Orlistat, in combination with a reduced-calorie diet and exercise, achieve significantly greater weight loss compared to those on a placebo or diet and exercise alone.

One study conducted over a 6-month period found that participants who took Orlistat lost an average of 10% of their body weight, while those in the placebo group only lost 6%. Additionally, nearly twice as many individuals in the Orlistat group achieved a weight loss of 5% or greater compared to the placebo group.

The mechanism of action of Orlistat is what makes it particularly effective for weight loss. By inhibiting the absorption of dietary fat, Orlistat reduces the number of calories that are absorbed from the food we eat. This ultimately leads to a reduction in calorie intake, creating a calorie deficit necessary for weight loss.

It is important to note that Orlistat is not a miracle pill for weight loss. It is most effective when used in conjunction with a healthy diet and regular exercise. Adopting a balanced and nutritious eating plan, along with engaging in physical activity, maximizes the benefits of Orlistat and helps individuals achieve their weight loss goals.

Like any medication, Orlistat may have potential side effects. The most common side effects associated with Orlistat include oily spotting, gas with discharge, and oily stools. These side effects are often manageable and can be minimized by following a low-fat diet while taking the medication.

Before starting Orlistat, it is crucial to consult with a healthcare provider. They can provide personalized guidance and determine if Orlistat is a suitable option based on an individual’s medical history and weight loss goals.

In conclusion, Orlistat is an effective weight-loss medication that inhibits the absorption of dietary fat in the body. It is commonly prescribed or recommended by healthcare providers for individuals seeking to lose weight. When used in combination with a reduced-calorie diet and exercise, Orlistat has been shown to promote significant weight loss. However, it is essential to consult with a healthcare provider before starting Orlistat to ensure its appropriateness and receive personalized guidance.

7. Side effects of Orlistat

While Orlistat can be an effective weight-loss medication, it is important to be aware of its potential side effects. Like any medication, Orlistat may cause unwanted reactions in some individuals. It is recommended to consult a healthcare professional before starting this medication to assess if it is suitable for you and to discuss potential side effects. Below are some common side effects associated with Orlistat:

  1. Gastrointestinal Issues: Orlistat works by blocking the absorption of dietary fat, which can result in gastrointestinal side effects such as oily spotting, flatulence, stomach pain, and diarrhea. These symptoms can be managed by following a low-fat diet and reducing the intake of high-fat meals.
  2. Changes in Bowel Habits: Some individuals may experience changes in bowel habits, including increased frequency of bowel movements and urgency.
  3. Deficiency of Fat-Soluble Vitamins: Orlistat can interfere with the absorption of fat-soluble vitamins, such as vitamins A, D, E, and K. To ensure adequate vitamin levels, it is important to supplement with these vitamins or consume foods rich in these nutrients.
  4. Headache: Headaches have been reported as a potential side effect of Orlistat, although they are generally mild and temporary.
  5. Back Pain and Muscle Aches: Some individuals have experienced back pain and muscle aches while taking Orlistat; however, these side effects are rare and usually resolve on their own.
  6. Allergic Reactions: Although rare, allergic reactions to Orlistat can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. In such cases, immediate medical attention should be sought.

It is important to remember that not all individuals will experience these side effects, and many people tolerate Orlistat well. However, if any of these side effects persist or worsen, it is advisable to seek medical advice.

Always consult your healthcare provider or pharmacist for comprehensive information on the side effects and precautions associated with Orlistat.

Effective Weight-Loss Medication – Orlistat Options, Safety Tips, and Cost-Saving Strategies

Overview of Orlistat

Orlistat is a commonly used medication for weight management that works by blocking the absorption of fat in the digestive system. It is sold under the brand names Xenical (prescription) and Alli (over-the-counter). The primary function of Orlistat is to prevent the body from absorbing dietary fats by inhibiting pancreatic lipase, an enzyme that breaks down fats in the intestine.

How Does Orlistat Work in Weight Management?

When Orlistat is taken with meals, it attaches to the enzymes in the digestive system and prevents them from breaking down some of the fat you eat. As a result, the unabsorbed fat is excreted from the body rather than being stored. This action can help promote weight loss when combined with a low-calorie diet.

Forms of Orlistat Available in the Market

There are two main forms of Orlistat available: prescription-strength Xenical and over-the-counter Alli. Xenical typically contains a higher dosage of Orlistat compared to Alli and is intended for individuals with a body mass index (BMI) of 30 or higher. Alli, on the other hand, is suitable for overweight adults with a BMI of 25-29.9.

Both Xenical and Alli have similar mechanisms of action and are designed to be used alongside a reduced-calorie diet. It is essential to follow the recommended dosage instructions and dietary guidelines when taking Orlistat to achieve the best weight loss results.

The Safest Weight-Loss Drug Options

When considering weight-loss drugs, it is important to prioritize safety and effectiveness. Here are some of the safest weight-loss drug options available:

  • Orlistat: Orlistat is a commonly prescribed weight-loss drug that works by blocking the absorption of fat in the body. It is available in both prescription and over-the-counter forms, such as Alli. Orlistat is generally well-tolerated but can cause gastrointestinal side effects like oily stools and flatulence.
  • Phentermine: Phentermine is a prescription medication that suppresses appetite and is typically used for short-term weight loss. It is considered safe when used under the supervision of a healthcare provider but may cause side effects like increased heart rate and insomnia.
  • Contrave: Contrave is a combination of bupropion and naltrexone that can help in weight management by reducing appetite and cravings. It is approved for long-term use but may have side effects such as nausea and headaches.
  • Liraglutide (Saxenda): Liraglutide is an injectable medication that helps with weight loss by slowing digestion and regulating appetite. It is generally well-tolerated but can cause nausea and diarrhea in some individuals.
  • Orlistat/Phentermine Combination: Some weight-loss medications combine Orlistat and Phentermine for dual action in reducing fat absorption and suppressing appetite. This combination may be effective for certain individuals but can also increase the risk of side effects.

While these weight-loss drugs have shown efficacy in aiding weight management, it is essential to consult with a healthcare provider before starting any medication regimen for weight loss. Monitoring for potential side effects and assessing individual health needs can help ensure safe and effective use of these drugs.

Tips for Reducing Drug Prices

1. Explore Generic Alternatives

One effective way to save money on medication costs is to consider using generic alternatives rather than brand-name drugs. Generic medications contain the same active ingredients as their brand-name counterparts but are typically much cheaper. According to a report by the Association for Accessible Medicines, generic drugs saved the U.S. healthcare system $313 billion in 2019 alone (source).

2. Take Advantage of Prescription Assistance Programs

Many pharmaceutical companies offer prescription assistance programs that provide discounts or vouchers for medications to eligible individuals. These programs can help reduce the out-of-pocket costs of prescription drugs. For example, Pfizer’s RxPathways program offers assistance to patients with limited financial resources (source).

3. Consider Online Pharmacy Discounts

Online pharmacies often provide discounts and promotions on medications that can help lower overall costs. By comparing prices and exploring different online pharmacy options, consumers can find cost-effective solutions for their prescription needs. Websites like GoodRx offer discounts on a wide range of medications (source).

4. Use Prescription Savings Cards

Patient savings cards, also known as prescription discount cards, can help reduce the price of medications at the pharmacy. These cards are typically free and can be used for both brand-name and generic drugs. Websites like SingleCare offer savings cards that can be used at major pharmacies such as CVS and Walgreens (source).

5. Opt for Larger Prescriptions

When possible, consider requesting a larger prescription supply from your healthcare provider. Buying medications in bulk often comes with cost savings, as pharmacies may offer discounts for larger quantities. Additionally, fewer trips to the pharmacy can save you time and money in the long run.

6. Ask About Assistance Programs

Government programs like Medicare, Medicaid, and the Supplemental Nutrition Assistance Program (SNAP) may offer assistance with prescription drug costs for eligible individuals. Contact your local social services agency or healthcare provider to inquire about available programs and eligibility criteria.

Benefits of Online Pharmacies:

Online pharmacies offer a range of benefits that can make acquiring medication more convenient and cost-effective. Here are some key advantages of using online pharmacies:

  1. Wide Variety of Medication Options: Online pharmacies typically have a larger selection of medications available compared to traditional brick-and-mortar pharmacies. This means that individuals can easily find the specific medication they need without having to visit multiple pharmacies.
  2. Cost Savings: Online pharmacies often provide more affordable medication options, as they have lower overhead costs compared to physical pharmacies. This can result in significant savings for consumers, especially for those who need to buy medications regularly.
  3. Convenience: One of the biggest advantages of online pharmacies is the convenience they offer. Individuals can order their medications from the comfort of their own home and have them delivered right to their doorstep. This eliminates the need to travel to a pharmacy and wait in line.

In addition to these benefits, online pharmacies also offer other advantages such as access to medication information, online consultations with healthcare professionals, and easy refill options.

According to a survey conducted by the National Association of Chain Drug Stores, 72% of consumers find online pharmacies convenient for purchasing medications.

Cost Comparison: Online vs. Traditional Pharmacies

Medication Online Pharmacy Price Traditional Pharmacy Price
Orlistat 120mg (30 capsules) $30 $40
Metformin 500mg (60 tablets) $25 $35
Simvastatin 20mg (30 tablets) $20 $30

As shown in the table above, purchasing medication from an online pharmacy can lead to significant cost savings compared to buying from a traditional pharmacy. These savings can add up over time, making online pharmacies a cost-effective option for individuals seeking affordable medication.

Overall, online pharmacies provide a convenient and cost-effective way for individuals to access a wide range of medications, including weight-loss drugs like Orlistat.

Utilizing Online Pharmacies to Save on Medication Costs

Online pharmacies can be a game-changer for individuals looking to save on medication costs, especially for those with limited financial resources. These digital platforms offer a wide range of benefits that contribute to significant savings and convenience for consumers.

Cost Savings

One of the primary advantages of online pharmacies is the cost savings they provide. By operating primarily in the digital space, online pharmacies have lower overhead costs compared to traditional brick-and-mortar pharmacies. This cost efficiency allows them to offer medications at discounted prices, making them a more affordable option for individuals seeking treatment.

Furthermore, online pharmacies often have special promotions, discounts, and loyalty programs that can further reduce the cost of medications. By taking advantage of these offers, individuals can save a substantial amount of money on their prescriptions.

Wide Variety of Medication Options

Online pharmacies typically offer a wide selection of medications, including both brand-name and generic options. Generic medications are cost-effective alternatives to brand-name drugs and can result in significant savings for consumers. Online pharmacies make it easy to compare prices and choose the most affordable option without compromising on quality or efficacy.

Convenience and Accessibility

Another key benefit of online pharmacies is the convenience they offer to consumers. With just a few clicks, individuals can order their medications online and have them delivered right to their doorstep. This eliminates the need to visit a physical pharmacy, saving time and effort for busy individuals.

Additionally, online pharmacies are accessible 24/7, allowing individuals to place orders at their convenience. This accessibility is particularly beneficial for individuals with hectic schedules or limited mobility, making it easier for them to access the medications they need.

Prescription Assistance Programs

Some online pharmacies participate in prescription assistance programs that provide additional financial support to individuals in need. These programs offer discounts, coupons, or other forms of assistance to help reduce the out-of-pocket costs of medications. By enrolling in these programs, individuals can further decrease their medication expenses and improve their affordability.

Overall, online pharmacies offer a cost-effective and convenient solution for individuals looking to save on medication costs. By leveraging the benefits of these digital platforms, individuals can access affordable medications and enhance their overall well-being without breaking the bank.

Comparison of Orlistat Options

When considering weight-loss drugs like Orlistat, it’s essential to understand the differences between the over-the-counter and prescription versions to make an informed decision about which option may be best suited for your needs.

Over-the-Counter Orlistat

  • Available under various brand names such as Alli, over-the-counter Orlistat is a lower-dose version of the prescription drug.
  • Works by blocking the absorption of fat in the digestive system, leading to reduced calorie intake and potential weight loss benefits.
  • Potential side effects of over-the-counter Orlistat include gastrointestinal issues such as oily stools, flatulence, and frequent bowel movements.

Prescription Orlistat

  • Prescription-strength Orlistat is typically recommended for individuals with a higher body mass index (BMI) or those who have not achieved significant weight loss with the over-the-counter version.
  • Offers a higher potency than the over-the-counter option, leading to potentially more substantial weight loss results.
  • Medical supervision is necessary when using prescription Orlistat to monitor for any adverse effects and ensure proper dosage.

It’s crucial to consult a healthcare provider before starting any weight-loss medication to determine the most suitable option based on individual health and weight loss goals. Both over-the-counter and prescription Orlistat can be effective tools for managing weight, but each comes with its own considerations regarding safety and efficacy.

As always, remember that weight loss should be approached holistically, incorporating a balanced diet, regular physical activity, and lifestyle modifications to achieve long-term success.

Conclusion: The Key Takeaways

In conclusion, it is crucial to make informed decisions when selecting weight-loss drugs like Orlistat. By considering factors such as effectiveness, safety, and potential side effects, individuals can choose the most suitable option for their weight management journey.
As highlighted in the previous sections, Orlistat comes in both over-the-counter and prescription forms, each with its own benefits and considerations. While over-the-counter Orlistat may be more accessible, prescription versions are often more potent and may be recommended for individuals with specific weight-loss goals or health conditions.
It is essential to consult healthcare professionals before starting any weight-loss medication to ensure it is appropriate for individual needs. Monitoring progress, managing side effects, and maintaining a healthy lifestyle are key aspects of a successful weight-loss journey with Orlistat or other weight-loss drugs.
Remember, weight management is a journey that requires dedication, consistency, and informed decision-making. By incorporating healthy eating habits, regular exercise, and support from healthcare providers, individuals can achieve their weight-loss goals effectively and safely.
In the end, the key to successful weight management lies in finding the right balance between medication, lifestyle changes, and ongoing support. Making informed choices and staying committed to long-term health and well-being will pave the way for sustainable weight loss and overall improved quality of life.